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About NCIRE - The Veterans Health Research Institute
NCIRE's Impact on Veterans Veteran's Health Research Researchers by Name
There's no question that the San Francisco VA Medical Center, with the support of NCIRE, plays a major role in advancing veterans health care through research. The excellence of our NCIRE and SFVAMC investigators, all of whom are UC San Francisco faculty members, is fundamental to our success in developing cutting edge knowledge that will advance medical treatments of veterans and others, both locally and worldwide.

Paul Volberding, MD
Chair, NCIRE Board of Directors
Chief of Medicine, SFVAMC

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Rajvir Dahiya, PhD

Research Scientist, Medical Research Service, SFVAMC
Professor of Urology, UCSF
Email: rdahiya@urology.ucsf.edu

Age, Race, and Prostate Cancer

Dr. Dahiya's research focuses on ways to identify and characterize genes that are epigenetically (reversibly) silenced in age-related prostate cancer. These genes may be used for early diagnosis and prognosis of the disease. Another use is to identify possible genetic and epigenetic risk factors for race-related prostate cancer. In one study, Dr. Dahiya investigated whether over- expression of the genes cytochrome P450 1A1 and cytochrome P450 1B1 are risk factors for race-related prostate cancer. In another recent study, Dr. Dahiya reported that the tumor suppressor gene GSTPI is inactivated at a significantly higher rate in African American prostate cancer patients than in Caucasian patients. These mechanisms provide potentially novel approaches to the management of prostate cancer.

Place RF, Li L-C, Pookot D, Noonan EJ, Dahiya R. 2008. MicroRNA-373 induces gene expression by targeting promoter sequences. Proc Natl Acad Sci USA 105:1608-1613.

Kawamoto K, Hirata H, Kikuno N, Tanaka, Y, Nakagawa M, Dahiya R. 2008. DNA methylation and histone modifications cause silencing of wnt antagonist gene in renal cell carcinoma. Inter J Cancer 123:535-542.