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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Zhongjian Xie, MD, PhD

Research Scientist, Medical Research Service, SFVAMC
Research Scientist, NCIRE

Associate Professor of Medicine, UCSF
Email: zhongjian.xie@ucsf.edu

Potential New Therapies for Squamous Cell Carcinoma

Calcium and vitamin D play a critical role in regulating differentiation and proliferation of keratinocytes. Dr. Xie's recent studies have focused on the mechanism by which calcium and vitamin D regulate proliferation, differentiation and carcinogenesis of keratinocytes. The mechanism involves molecular interactions between calcium or vitamin D signaling and epidermal growth factor receptor signaling. Information obtained from these studies will bring the possibility of new therapeutic options for the control of diseases of disordered proliferation and differentiation of keratinocytes such as squamous cell carcinoma.

To see Dr. Xie on Pub Med, click here.