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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Ruby Ghadially, MBCHB, FRCP

Staff Physician, Dermatology Service, SFVAMC
Professor of Dermatology, UCSF

Email: ruby.ghadially@va.gov

Characterization of Human and Murine Stem Cells to Treat Skin Conditions and Cancer

Dr. Ghadially's laboratory focuses on the characterization of normal stem cells for the purposes of understanding epidermal biology and for regenerative medicine applications, including therapy for burns, wounds, and/or ulcers, as well as effectively targeting a long-lasting cell for gene therapy. Her laboratory also studies the tumor initiating cell (cancer stem cell) responsible for the generation of melanoma tumor cells, as well as the cells that resist chemotherapy. For these studies, Dr. Ghadially and her colleagues examined stem cell markers utilized in other tumors and have obtained an enriched population of melanoma initiating cells from human melanomas. Rather than aiming for bulk tumor destruction, the melanoma initiating cell is the cell to target in order to cure people of this neoplastic condition.

To see Dr. Ghadially on Pub Med, click here.