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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Robert A. Nissenson, PhD

Senior Research Career Scientist, Medical Research Service, SFVAHCS
Professor of Medicine and Physiology, UCSF

Novel Approaches to Stimulating Bone Formation

Dr. Nissenson and his colleagues are identifying new pathways to activate osteoblasts - the cells that make new bone - in order to more effectively treat osteoporosis (loss of bone density with age) and to accelerate fracture repair. They have found that activation of one of these pathways results in a massive increase in bone formation and in the size of bones. Growing bones are most sensitive to activation of this pathway, but adult bone also displays a marked increase in size and bone mass. Pharmacological agents that target this pathway may prove to be useful in the treatment of osteoporosis and in promoting bone formation during fracture repair.

To see Dr. Nissenson on Pub Med, click here.