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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Paul C. Simpson, MD

Staff Physician, Cardiology, SFVAMC
Professor of Medicine, UCSF

Email: paul.simpson@ucsf.edu

New Treatments for Heart Failure

Dr. Simpson is interested in discovering new drugs to treat heart failure, one of the most common causes of hospitalization and death in veterans.  In the 1980s, Dr. Simpson developed a new in vitro culture model of heart failure.  Using this model, and later genetically altered mice and other animals, he showed that a type of receptor for adrenalin has marked adaptive and protective effects in heart muscle cells.  In some ways, stimulating this receptor on heart muscle cells has beneficial effects similar to exercise.  This finding correlates with clinical trials showing that blocking this receptor in human patients causes heart failure.  His lab is now using animal models to test the idea that a drug activating this receptor can prevent and treat heart failure.  If this work is successful, the idea can be extended to patients, since humans have the same receptor as mice.  This work can lead to a new drug to treat heart failure.

To see Dr. Simpson on Pub Med, click here.

To learn more about Dr. Simpson and his work, click here.