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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Midori A. Yenari, MD

Staff Physician, Neurology Service, SFVAHCS
Professor of Neurology, UCSF


Protecting the Brain from Injury

There are few treatments for conditions such as stroke and head trauma. Dr. Yenari's lab focuses on various strategies to limit the amount of brain injury that results from ischemia. The focus of the Yenari lab has centered around the role of inflammation, and how immune responses contribute to brain ischemia and injury. Among potential interventions, therapeutic hypothermia, the technique of cooling the brain a few degrees, is not only protective, but also has significant effects on suppressing inflammation. Other areas of interest include how microglia and leukocytes cause worsening of brain injury, as well as how other immune molecules may be important in the brain's recovery following injury. These immune modulating molecules include the 70 kD heat shock protein and triggering receptor expressed on myeloid cells-2 (TREM-2).

To see Dr. Yenari on Pub Med, click here.