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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Mark Ratcliffe, MD

Staff Physician, Chief of Surgery, SFVAHCS
Professor and Vice-Chair of Surgery, UCSF

Email: mark.ratcliffe@va.gov

Cardiac Ventricular Remodeling Surgery

Dr. Ratcliffe was the first cardiac surgeon to use realistic mathematical models to evaluate the efficacy of novel surgical procedures for the treatment of heart failure and ischemic heart disease. One evaluation was of the Myocor Myosplint, a device designed to change left ventricular (LV) shape and reduce heart wall stress. Using a mathematical model, Dr. Ratcliffe found that Myosplint should be much more effective than partial ventriculectomy as a surgical therapy for patients with dilated cardiomyopathy and end-stage congestive heart failure. Dr. Ratcliffe also mathematically analyzed surgical anterior ventricular restoration (SAVER), another surgical treatment for heart failure, and determined the circumstances under which it can be used most effectively. These studies will help surgeons develop surgical remodeling procedures that might decrease LV wall stress and improve LV function in heart failure patients. Dr. Ratcliffe continues to model and evaluate other novel cardiac surgical procedures.

To see Dr. Ratcliffe on Pub Med, click here.