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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Mao-Qiang Man, MD

Research Scientist, SFVAHCS

Epidermal Permeability Barrier

Dr. Man has been conducting research on the epidermal permeability barrier for over 25 years, working in collaboration with Dr. Elias, the foremost expert in the stratum corneum. Through his research, Dr. Man has shown that the epidermal permeability barrier plays a crucial role in the pathogenesis of certain skin disorders and that improvement of the permeability barrier offers a novel approach to prevent and treat these dermatoses. He has discovered that mixtures containing optimal ratios of stratum corneum lipids improve epidermal function, with widespread clinical applications from daily skincare products to preventive/therapeutic regimens for skin disorders. Recently he identified several natural ingredients that benefit epidermal functions and dermatitis. It is of particular significance that his works have made it possible to overcome long-standing challenges in improving epidermal functional abnormalities in both normal-aged skin and glucocorticoid-treated skin.

To see Dr. Man on PubMed, click here.