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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Kenneth Feingold, MD

Staff Physician, Medical Service, SFVAHCS
Professor of Medicine, UCSF
Email: kenneth.feingold@ucsf.edu

The Role of Lipids and Lipoproteins in Inflammation and Skin Formation

Lipoproteins are considered part of innate immunity, participating in inactivation of bacteria, viruses, and parasites. Infection and inflammation are associated with multiple alterations in lipid and lipoprotein metabolism. The initial purpose of these alterations is to protect the host from the harmful effects of the injurious stimuli. However, in chronic infection or inflammation, these changes could be harmful and may contribute to atherosclerosis (arterial plaque). Dr. Feingold's laboratory works to define a) the alterations in lipid and lipoprotein metabolism that occur during inflammation, b) the mechanisms that account for the changes, c) the beneficial effects of the changes, and d) the pathways by which the inflammation induced changes in lipid metabolism increases the risk of developing atherosclerosis. Another major goal of his research is to understand the role of lipids in formation of the stratum corneum (SC) - the outermost layer of skin - which in turn generate the epidermal permeability barrier, which is required for terrestrial life. It is anticipated that these studies will point to novel therapies that could improve stratum corneum and permeability barrier function.

To see Dr. Feingold on Pub Med, click here.