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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Julius M. Guccione, PhD

Research Scientist, Surgical Service, SFVAHCS
Associate Professor of Surgery, UCSF


Measuring and Improving Cardiac Function through Bioengineering

Dr. Guccione studies the role of stem cell transplantation on the biophysics of cardiac function and the use of mechanical engineering principles in the diagnosis and treatment of cardiac disease. He is Co-director of the SFVAMC Cardiac Biomechanics Laboratory, which uses a combination of mathematical modeling and animal experiments to determine the effect of cardiac surgery on left ventricular function and remodeling. He is also a Core member of the UCB/UCSF Joint Graduate Group in Bioengineering. Current projects involve testing and validating a software tool for determining myocardial material properties in vivo using cardiac catheterization and magnetic resonance imaging, and determining the effects of three different surgical treatments on function and regional mechanics in sheep.

Dr. Guccione is co-editor of Computational Cardiovascular Mechanics, which is the first book to comprehensively address heart failure from a computational modeling perspective.

To see Dr. Guccione on Pub Med, click here.