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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Jian Shi, PhD

Research Neuroscientist, Neurology Service, SFVAHCS
Assistant Professor of Neurology, UCSF

Novel strategies for the Chronic Traumatic Encephalopathy

Traumatic brain injury (TBI) is a leading cause of mortally and morbidity in modern warfare. TBI is also a major cause of death and disability in the US, in particular in those under age 40, and ~2% of the US population is living with a chronic TBI-related disability. It is well recognized that a significant percentage of patients including active duty service members (ADSM) and veterans, after sustaining ‘mild’ traumatic injury (mTBI) may complain of a syndrome including poor concentration, memory dysfunction, and altered mood that may persist for years, which may be defined as the chronic traumatic encephalopathy (CTE).  In fact, the long-term pathological consequences of CTE have remained underexplored. In particular, whether chronic post traumatic processes exacerbate chronic neuroinflammation and suppressed neurogenesis is not fully understood.  Dr. Shi is focus on the molecular and cellular mechanisms, and novel treatment strategies related to neurogenesis, cell death and inflammation following CTE.


To see Dr. Shi on Pub Med, click here.