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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Jialing Liu, PhD

Research Career Scientist, Surgery Service, SFVAHCS
Professor of Neurological Surgery, UCSF


Improving Functional Recovery Following Stroke or Traumatic Brain Injury

Dr. Liu's fields of research include neurogenesis, regeneration, brain plasticity, and functional recovery in the context of stroke, hypoglycemia, and traumatic brain injury (TBI). She is one of the leading investigators studying the molecular mechanisms underlying neurogenesis, regeneration, cell death, and neurovascular remodeling after ischemic stroke. Due to the common occurrence of these types of brain injuries in our veteran population, her research is highly relevant to the mission of VA healthcare. Dr. Liu has tackled fundamental issues in how the brain recovers from injury from several key directions. A substantial amount of her early work was in understanding the pathophysiological mechanisms underlying the initial response to, and progression of, brain injury. Dr. Liu's team was the first group to show that cerebral ischemia - interruption of blood flow - increases the formation of new brain cells in the dentate gyrus in an experimental model. Many laboratories have subsequently confirmed this finding in animal models. At present, the strategy of promoting neuronal regeneration via endogenous neural stem/progenitor cells holds promise for patients suffering from stroke; however, many questions remain as to how enhanced neurogenesis can be achieved and how it is involved in the recovery of function. Establishing the mechanistic basis and signaling pathways involved in mediating neurogenesis has become the main mission of Dr. Liu's recent and ongoing research.

To see Dr. Liu on Pub Med, click here.