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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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James A. Frank, MD

Staff Physician, Medical Service, Director, Medical Intensive Care Unit, SFVAHCS
Professor of Medicine, UCSF

Email: james.frank@va.gov

New Therapies for Common but Poorly Understood Lung Diseases

Dr. Frank cares for patients in the intensive care unit at the San Francisco VA Medical Center and directs a research program with the goal of developing new treatments and diagnostics for lung diseases. Dr. Frank's research team investigates the waya in which the lung maintains a barrier between the body and the outside world. Defects in this barrier in the lung contribute to several lung diseases common to the veteran population, including pulmonary fibrosis, asthma, and the acute respiratory distress syndrome (ARDS). ARDS is a common and devastating syndrome of respiratory failure that results from infections such as influenza and bacterial pneumonia, but also from sepsis, aspiration, toxic inhalations, and trauma. Current medical therapies for each of these lung diseases are inadequate and innovation is needed to improve patient outcomes. By discovering the causes of lung barrier dysfunction, this research team aims to develop better therapies for patients.

To see Dr. Frank on Pub Med, click here.