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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Deborah Grady, MD, MPH

Staff Physician, Medical Service, SFVAMC
Professor of Epidemiology and Medicine, UCSF
Email: deborah.grady@ucsf.edu

Risks and Benefits of Postmenopausal Hormone Therapy

Dr. Grady is one of the world's leading experts on the risks and benefits of postmenopausal hormone therapy. In 1992, she developed evidence-based guidelines for use of postmenopausal hormone therapy for the American College of Physicians. With minor changes, these guidelines were adopted by the American College of Family Practice, the American Heart Association and the US Preventive Services Task Force. However, Dr. Grady and others felt that a randomized trial was imperative. She subsequently played a lead role in designing and conducting the Heart and Estrogen/progestin Replacement Study (HERS), the first randomized trial of the effect of estrogen therapy on risk for heart disease events. Surprisingly, this 20-center 7-year trial among 2,763 postmenopausal women with coronary disease showed no benefit of estrogen plus progestin therapy, and a 3-fold increased risk of blood clots. Dr. Grady has also investigated the effect of postmenopausal hormone therapy on cognition, dementia, and a variety of other clinical outcomes, and written extensively on the rational clinical use of hormones.

To see Dr. Grady on Pub Med, click here.