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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Daniel A. Lim, MD, PhD

Staff Physician, Surgery Service, SFVAHCS
Assistant Professor of Neurological Surgery, Director of Restorative Neurosurgery, UCSF

Email: Daniel.Lim@va.gov

Programming Stem Cells for the Genesis of New Neurons

Dr. Lim is the principal investigator of a laboratory that studies the epigenetic (genetic changes not involving DNA sequencing) control of neural stem cell fate.  Since 1996, he has been studying the cellular and molecular biology of adult brain neural stem cells in a region of the brain called the subventricular zone.  For neural stem cells to make neurons, daughter cells need to express certain sets of genes while repressing others.  The establishment of such lineage-specific transcriptional programs is in part regulated by chromatin structure - the "packaged" state of DNA with histone proteins.  His current research is focused on a chromatin remodeling factor called MLL1, which he has recently shown to be essential for the genesis of new neurons from postnatal brain stem cells.  Dr. Lim's long-term research goals are to define the genetic programs and molecular mechanisms for the birth of new neurons from adult brain stem cells, and to translate these discoveries into cell and genetic therapies for neurodegenerative disease and injury. 

To see Dr. Lim on Pub Med, click here.