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Research at NCIRE

NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Daniel Cook, MD

Staff Physician, Chief of Section Neurointerventional Radiology
Assistant Professor of Radiology and Biomedical Imaging
University of California San Francisco
Chief of Section Neurointerventional Radiology
San Francisco General Hospital

Diagnosis and Treatment of Neurovascular Disorders

I practice as a neurointerventional radiologist with clinical and research focuses on the characterization of the pathophysiology of aneurysms and shunting vascular lesions within the brain and spine, namely arteriovenous malformations and arteriovenous fistulae. On a research level, I pursue these goals through epidemiological, advanced imaging, and molecular analytical methods. I have existing basic science projects looking at the gene expression from aneurysmal endothelial cells, temporal onset of AVMs using carbon-dating methods, and the role of neural stem cells in AVM formation and/or recurrence. I have advanced imaging projects investigating the role of flat-panel CT angiographic based methods for computational flow-dynamics of aneurysms, transcranial guidance for intervention, and quantiative brain blood-flow. I am currently developing clinical trials focused on the role of medical therapies in non-surgical AVMs and aneurysms. Lastly, I also work on a number of translational projects aimed at developing new image-guided devices and interventional techniques for the management of stroke. Some of these include the design of a minimally invasive catheter-based system for the evacuation of intracerebral hemorrhage, development of viral-vector embedded embolic agents for targeted gene delivery, and novel methods for collection of endothelial cells from endovascular devices.

To see Dr. Cook on Pub Med, click here.